Avoid using Promethazine HCl and Codeine Phosphate Oral Solution in adolescents 12 to 18 decades of age who have other risk things that could boost their sensitivity on the respiratory depressant effects of codeine Except if the advantages outweigh the risks.
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The precise system of action of codeine along with other opiates just isn't acknowledged; however, codeine is believed to act centrally over the cough Heart. In excessive doses, codeine will depress respiration.
Hold out in the arrive at of children and Animals. This medication could be abused. Keep it in a secure spot to shield it from theft. Don't share it with any one. It is just for you personally. Offering or giving away this medication is perilous and from the legislation.
Codeine wasn't mutagenic in the in vitro bacterial reverse mutation assay or clastogenic while in the in vitro Chinese hamster ovary (CHO) cell chromosomal aberration assay.
The causal role of opioids inside the scientific syndrome of hypogonadism is unfamiliar because the many health-related, Bodily, Life-style, and psychological stressors that may impact gonadal hormone concentrations have not been sufficiently controlled for in scientific tests done up to now [see Adverse Reactions (6)].
Tend not to flush medicines down the toilet or pour them into a drain Until instructed to do so. Appropriately discard this merchandise when it is expired or no more necessary. Consult your pharmacist or area waste disposal company.
Promethazine Promethazine codeine syrup HCl and Codeine Phosphate Oral Remedy must be applied with caution in sufferers with bone- marrow despair. Leukopenia and agranulocytosis are claimed, typically when promethazine continues to be Employed in association with other known marrow-toxic agents.
Postmarketing instances of respiratory despair, like fatalities are claimed with utilization of promethazine in pediatric individuals.
If you're quite sleepy or have problems waking up right after applying this medication, quit having this medication and talk to your physician or pharmacist straight away. Your dosage may well must be lessen.
Because narcotic analgesics may increase biliary tract stress with resultant improves in plasma amylase or lipase levels, determination of those enzyme concentrations could be unreliable for 24 hrs following a narcotic analgesic has long been given.
Just before making use of this medication, Women of all ages of childbearing age must speak with their physician(s) concerning the hazards and Rewards. Convey to your health care provider Should you be Expecting or Imagine you might be pregnant. Throughout pregnancy, this medication isn't recommended. It may well a bit enhance the hazard of start defects if applied in the course of the very first two months of pregnancy. Also, working with it for years or in high doses close to the predicted shipping date might harm the unborn little one.
Never instantly halt taking your medication simply because you could create a serious response. Your whole body gets to be used to the medication. This doesn't indicate you might be addicted. Habit is a conduct linked to getting and utilizing a medication for any nonmedical rationale.